Contraindicated (1)pentobarbital will decrease the level or effect of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the level or effect of brexpiprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Double brexpiprazole dose around one-two months if adm